The ECARE project will develop and disseminate methodologies to create synergy mechanisms applicable to all EU aeronautical regions. These methodologies will be designed and tested in a Pilot involving four major regions of the European aeronautical industry, namely Occitanie and Nouvelle-Aquitaine in France, Hamburg in Germany and Campania in Italy. Over the course of the project, the methodologies will be improved, adapted and tested against the realities of these four regions, turning ECARE into a mature operational guidance project for CA JU and other European regions and countries.