The ECARE project developed and disseminated methodologies to create synergy mechanisms applicable to all EU aeronautical regions. These methodologies were designed and tested in a Pilot involving four major regions of the European aeronautical industry, namely Occitanie and Nouvelle-Aquitaine in France, Hamburg in Germany and Campania in Italy. Over the course of the project, the methodologies were improved, adapted and tested against the realities of these four regions, turning ECARE into a mature operational guidance project for CA JU and other European regions and countries.